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The Best of San Francisco in 48 hours: a 2 day itinerary. Click to get the Bucket List: 25 Family-Friendly Things to Do in San Francisco #sanfrancisco #sf #familytravel #travelwithkids // Family Travel | Travel with Kids | San Francisco with Kids | California Travel | Bay Area Kid Activities | Travel with Toddlers | Travel with Baby | Best Things to Do in San Francisco | Top Things to See | Where to Stay | US Travel | Northern California Let me start off by saying that I don’t recommend only spending 48 hours in San Francisco. The city is too great and there’s just so much to explore!